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      Item #: 50242-070-01
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      Gazyva (obinutuzumab) is a member of the CD20 monoclonal antibodies drug class and is commonly used for Chronic Lymphocytic Leukemia, and Follicular Lymphoma.

      Adult Dosing

      Dosage forms: INJ

      Special Note

      [uses, dosing may vary]Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments

      CLL/SLL, previously untreated

      [1000 mg IV x1 on day 1 of 28-day cycle, starting cycle 2]Start: 100 mg IV x1 on day 1, then 900 mg IV x1 on day 2, then 1000 mg IV x1 on days 8, 15 of 28-day cycle for cycle 1; Info: give x6 cycles; use w/ acalabrutinib, chlorambucil, ibrutinib, or venetoclax

      follicular lymphoma, relapsed

      [1000 mg IV q2mo up to 24mo, starting after 1st 6 cycles complete]Start: 1000 mg IV x1 on days 1, 8, 15 of 28-day cycle for cycle 1, then 1000 mg IV x1 on day 1 of 28-day cycle x5 cycles; Info: use w/ bendamustine for 1st 6 cycles

      follicular lymphoma, previously untreated

      [combo w/ bendamustine]Dose: 1000 mg IV q2mo up to 24mo, starting after 1st 6 cycles complete; Start: 1000 mg IV x1 on days 1, 8, 15 of 28-day cycle for cycle 1, then 1000 mg IV x1 on day 1 of 28-day cycle x5 cycles; Info: use w/ bendamustine for 1st 6 cycles[combo w/ CHOP]Dose: 1000 mg IV q2mo up to 24mo, starting after 1st 8 cycles complete; Start: 1000 mg IV x1 on days 1, 8, 15 of 21-day cycle for cycle 1, then 1000 mg IV x1 on day 1 of 21-day cycle x7 cycles; Info: use w/ CHOP for 1st 6 cycles[combo w/ CVP]Dose: 1000 mg IV q2mo up to 24mo, starting after 1st 8 cycles complete; Start: 1000 mg IV x1 on days 1, 8, 15 of 21-day cycle for cycle 1, then 1000 mg IV x1 on day 1 of 21-day cycle x7 cycles; Info: use w/ CVP for 1st 8 cycles

      renal dosing

      [see below]renal impairment: no adjustmentHD/PD: not defined

      hepatic dosing

      [not defined]

      Peds Dosing .

      Peds dosing is currently unavailable or not applicable for this drug.

      Contraindications / Cautions .

      • hypersens. to drug/class/compon.
      • active infection
      • breastfeeding during tx and x6mo after D/C
      • caution in female pts of reproductive potential
      • caution if chronic or recurrent infection
      • caution if HBV carrier
      • caution if thrombocytopenia
      • caution if neutropenia
      • caution if lymphocytes >25 x 10^9/L
      • caution if high tumor burden
      • caution if renal impairment
      • caution if cardiovascular dz or hx
      • caution if pulmonary dz or hx

      Drug Interactions .

      Overview

      obinutuzumab

      Interaction Characteristics:

      • hypotensive effects
      • immunosuppressive oncologic agent
      • myelosuppressive oncologic agent

      Gazyva (obinutuzumab) es un miembro de la clase de fármacos anticuerpos monoclonales CD20 y se usa comúnmente para la Leucemia linfocítica Crónica y el Linfoma folicular.

      Este artículo debe enviarse registrado "Cadena de frío" y mantenerse en almacenamiento en frío: 2-8 grados Celsius

      1 vial, single-use 40 mL in 1 carton 
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      1 vial, 40 mL de un solo uso en 1 caja